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AS/MSD-001 - Confirmation of Mass Information for Chlorhexidine

Confirmation of Mass Information for Chlorhexidine

Chromaster 5610 MS detector is a new mass detector, designed for LC users, and it is different from conventional mass spectrometers. With this detector and a syringe pump, a sample solution is introduced directly to 5610 MS Detector and the mass information can be obtained. This time, the analysis example of chlorhexidine, a main component of antibacterial disinfectants, is introduced here. A protonated molecular ion could be confirmed by simple operation.

5610 MS Detector

Infusion measurement of Chlorhexidine

n   Analytical Conditions

Ionization method


Ionization mode


Ionization voltage

2300 V

Measurement mode


Gas flow rate

0.7 L/min

IS/AIF temperature

100 ?C / 120 ?C

Pump flow rate

2 μL/min

Table 1 MS Detector Setting Conditions

n   Sample Preparation




1 mg/mL



Fig. 1 Structure Formula of Chrorhexidine

MS Spectrum

Fig. 3 Mass Spectrum of Chlorhexidine

Measurement Method

By connecting the syringe pump and MS Detector, the sample solution is directly delivered.

A protonated molecular ion, [M+H]+, and an isotope peak were observed. MS information can be obtained by a few milliliters sample volume, by saving the effort of starting up LC.

Main system configuration: Chromaster 5610 MS Detector, Syringe pump, Data processing unit

Product Info: Hitachi 5610 MSD

For more information on Hitachi MSD, please visit Hitachi High-Tech Science website


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