Home· · ·Techcomp college· · ·Application notes
Application notes
Scion AN0022 - The Analysis of Residual Solvents by Headspace Sampling and GC According to USP 467:
The Analysis of Residual Solvents by Headspace Sampling and GC According to USP 467: Procedure A
In the pharmaceutical industry, residual solvents are defined as organic volatile chemicals that are produced during the manufacturing of active pharmaceutical ingredients or derive d directly from the packaging of the pharmaceuticals Residual
solvents do not provide any therapeutic benefits and should be removed where possible.
The SCION 456 GC with Teledyne Tekmar HT3 headspace
autosampler exceeds the requirements for procedure A of USP 467 method, for the
identification of residual solvents Processing of the data and determining
specific requirements of the method is made easy using CompassCDS software The
excellent sensitivity satisfies the S/N requirements of USP 467 Identifying
residual solvents at the varying ppm concentrations specified in the method, is
easily achievable without saturating the detector or loss of resolution.