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Why Triple Quadrupole Mass Spectrometry is a Better Choice than Single Quadrupole

Multiple Reaction Monitoring (MRM) using a triple quadrupole mass spectrometer provides several advantages over Selected Ion Monitoring (SIM) using a single quadrupole mass spectrometer. By incorporating double mass filtering and MS/MS detection, triple quadrupole MS/MS offers higher selectivity and less interference from co-eluting compounds and matrix components, reducing the need for extensive method development and enabling faster analysis times. This technology also enables quantitation with lower limits of quantitation (LOQ) due to improved signal-to-noise ratios.
Moreover, triple quadrupole GCMS TQ 8900 requires fewer ions per compound for confirmatory analysis, with the EU Commission Decision mandating detection of 2 MRM transitions and 4 SIM transitions, respectively. This technology offers greater sensitivity than SIM, allowing for identification of lower-level analytes, with a difference of at least two orders of magnitude. Lastly, triple quadrupole MS/MS delivers a wider linear range, improved accuracy, and reproducibility in comparison to single quadrupole SIM.
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