×
×
×
×
×

Home· · ·Techcomp college· · ·Application notes

Application notes
AS/MSD-001 - Confirmation of Mass Information for Chlorhexidine

Confirmation of Mass Information for Chlorhexidine


Chromaster 5610 MS detector is a new mass detector, designed for LC users, and it is different from conventional mass spectrometers. With this detector and a syringe pump, a sample solution is introduced directly to 5610 MS Detector and the mass information can be obtained. This time, the analysis example of chlorhexidine, a main component of antibacterial disinfectants, is introduced here. A protonated molecular ion could be confirmed by simple operation.


5610 MS Detector


Infusion measurement of Chlorhexidine


n   Analytical Conditions


Ionization method

ESI

Ionization mode

Positive

Ionization voltage

2300 V

Measurement mode

Scan

Gas flow rate

0.7 L/min

IS/AIF temperature

100 ?C / 120 ?C

Pump flow rate

2 μL/min

Table 1 MS Detector Setting Conditions



n   Sample Preparation

Chrolhexidine:

C22H30Cl2N10

Concentration:

1 mg/mL

Solvent:

CH3OH


Fig. 1 Structure Formula of Chrorhexidine

MS Spectrum

Fig. 3 Mass Spectrum of Chlorhexidine

Measurement Method

By connecting the syringe pump and MS Detector, the sample solution is directly delivered.


A protonated molecular ion, [M+H]+, and an isotope peak were observed. MS information can be obtained by a few milliliters sample volume, by saving the effort of starting up LC.


Main system configuration: Chromaster 5610 MS Detector, Syringe pump, Data processing unit



Product Info: Hitachi 5610 MSD


For more information on Hitachi MSD, please visit Hitachi High-Tech Science website

https://www.hitachi-hightech.com/global/product_detail/?pn=ana-chromaster-5610

Online PDF reading

Online PDF reading

top
Micro-blog Sina Facebook

Contact UsMore

Hong Kong
  • 2606, 26/F., Tower 1, Ever Gain Plaza, 88 Container Port Road, Kwai Chung, N.T., Hong Kong
  • +852-27519488 / WhatsApp/WeChat HK: +852-6132 1139
  • techcomp@techcomp.com.hk
Beijing
  • 2 International Business Park, #09-06 Tower 1 The Strategy, Singapore 609930
  • +65-62678921
  • techcomp@techcomp.com.sg

powered by HuaHao

All Right Reserved 1988-2018©TECHCOMP GROUP
× Sweep The Concern Us